Active Ingredient: Rituximab Chronic lymphocytic leukemia: Treatment of previously untreated or previously treated CD20-positive chronic lymphocytic leukemia (CLL) (in combination with fludarabine and cyclophosphamide).
Granulomatosis with polyangiitis: Treatment of granulomatosis with polyangiitis (GPA; Wegener granulomatosis) (in combination with glucocorticoids).
Microscopic polyangiitis: Treatment of microscopic polyangiitis (MPA) (in combination with glucocorticoids).
Non-Hodgkin lymphomas: Treatment of CD20-positive non-Hodgkin lymphomas (NHL):
Relapsed or refractory, low-grade or follicular B-cell NHL (as a single agent)
Follicular B-cell NHL, previously untreated (in combination with first-line chemotherapy, and as single-agent maintenance therapy if complete or partial response to first-line rituximab with chemotherapy)
Nonprogressing (including stable disease), low-grade B-cell NHL (as a single agent after first-line CVP treatment)
Diffuse large B-cell NHL, previously untreated (in combination with CHOP chemotherapy [or other anthracycline-based regimen])
Rheumatoid arthritis: Treatment of moderately to severely active rheumatoid arthritis (in combination with methotrexate) in adult patients with inadequate response to one or more TNF antagonist therapies.
Limitations of use: Rituximab is not recommended for use in patients with severe, active infections.